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Chemical Structure : Myomed-946
Catalog No.: PC-38107Not For Human Use, Lab Use Only.
MyoMed-946 is a small moelcule that inhibits MuRF1 (TRIM63) activity and MuRF1/MuRF2 expression.
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MyoMed-946 is a small moelcule that inhibits MuRF1 (TRIM63) activity and MuRF1/MuRF2 expression.
MyoMed-946 inhibits MuRF1 expression/activity in vivo and is able to attenuate skeletal muscle atrophy and dysfunction in mice treated with monocrotaline to induce right ventricular hypertrophy and subsequent cardiac cachexia.
MyoMed-946 attenuates skeletal muscle strength loss in mouse model for type 2 diabetes mellitus (T2DM), with no significant effects on serum glucose.
MyoMed-946 attenuates induction of MuRF1 in tumor stressed muscles.
MyoMed-946 also rescues citrate synthase and complex-1 activities in tumor-stressed muscles.
MuRF1 (muscle-specific RING finger protein-1) is a muscle-specific ubiquitin ligase that regulates muscle catabolism during chronic wasting states, both MuRF1 and MuRF2 participate in glucose and, also, in lipid regulation.
| M.Wt | 490.468 | |
| Formula | C26H22N2O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Eva Zaccariotto, et al. J Cachexia Sarcopenia Muscle. 2022 Mar 17.
2. Adams V, et al. Cells. 2020 Oct 11;9(10):2272.
3. Labeit S, et al. Int J Mol Sci. 2021 Feb 23;22(4):2225.
4. Bowen TS, et al. J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):939-953.
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