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Chemical Structure : N1-hexyl-N5-benzyl-biguanide mesylate
Catalog No.: PC-61908Not For Human Use, Lab Use Only.
N1-hexyl-N5-benzyl-biguanide mesylate (HBB) is a potent and specific inhibitor of CYP3A4 AA epoxygenase activity with IC50 of 9.5 uM for inhibition of CYP3A4-mediated (±)-14,15-EET synthesis.
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N1-hexyl-N5-benzyl-biguanide mesylate (HBB) is a potent and specific inhibitor of CYP3A4 AA epoxygenase activity with IC50 of 9.5 uM for inhibition of CYP3A4-mediated (±)-14,15-EET synthesis; displays significantly higher for CYP2C8 (IC50=45 uM), and does not inhibit the AA epoxygenase activity of CYP2J2; inhibits MCF-7 cell line and ER+ and triple-negative breast cancer cell lines with similar IC50 (20 uM); strongly inhibits the oxygen consumption rate (OCR) and suppresses ATP stores, rapidly activates pAMPK and inhibits Stat3, mTOR, and ERK; inhibits MCF-7 xenograft tumor growth (24 mg/kg/week i.p.).
| M.Wt | 371.5 | |
| Formula | C16H29N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Guo Z, et al. Cell Chem Biol. 2017 Oct 19;24(10):1259-1275.e6.
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