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N205

Chemical Structure : N205

CAS No.:

N205 (N-205;N 205)

Catalog No.: PC-35114Not For Human Use, Lab Use Only.

N205 is a novel anti-malaria compound with in vitro IC50 of 1.3 nM against Plasmodium falciparum (3D7).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

N205 is a novel anti-malaria compound with in vitro IC50 of 1.3 nM against Plasmodium falciparum (3D7); demonstrates excellent rodent pharmacokinetic and in vivo antimalarial efficacy studies in the mouse Plasmodium berghei and Plasmodium falciparum Pf3D70087/N9 severe combined immunodeficiency (SCID) mouse models.

Physicochemical Properties

M.Wt 455.595
Formula C27H37NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(4-((1r,3r,5r,7r)-dispiro[adamantane-2,3'-[1,2,4,5]tetraoxane-6',1''-cyclohexan]-4''-yl)benzyl)morpholine

References

1. O' Neill PM, et al. Bioorg Med Chem. 2018 May 17. pii: S0968-0896(18)30203-7.

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