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Chemical Structure : NAB2
Catalog No.: PC-49510Not For Human Use, Lab Use Only.
NAB2 (Nedd4 inhibitor NAB2) is a specific small molecule inhibitor of E3 ubiquitin ligase Nedd4 with binding KD of 42 nM.
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NAB2 (Nedd4 inhibitor NAB2) is a specific small molecule inhibitor of E3 ubiquitin ligase Nedd4 with binding KD of 42 nM.
NAB2 rescues α-synuclein-associated trafficking defects associated with early onset Parkinson's disease in a Nedd4-dependent manner.
NAB2 binds to Dedd4 side chain and does not alter its conformation or ubiquitination kinetics in vitro, does not alter its co-localization with trafficking organelles.
| M.Wt | 389.88 | |
| Formula | C23H20ClN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hatstat AK, et al. Cell Chem Biol. 2021 Jan 21;28(1):14-25.e9.
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