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Chemical Structure : NADI-351
CAS No.: 2503017-11-4
Catalog No.: PC-72454Not For Human Use, Lab Use Only.
NADI-351 is a specific small-molecule inhibitor of Notch1 transcriptional complexes with IC50 of 8.8 uM in cellualr reporter assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $398 | In stock | |
| 10 mg | $558 | In stock | |
| 25 mg | $898 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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NADI-351 is a specific small-molecule inhibitor of Notch1 transcriptional complexes with IC50 of 8.8 uM in cellualr reporter assays.
NADI-351 inhibited OE33 cell growth in single dose MTT assays (EC50= 10 uM) and, more potently, in multi-dose colony formation assays (EC50=1.3 uM)
NADI-351 is 15 times more potent than IMR-1 in an NTC AlphaScreen assay.
NADI-351 selectively disrupted Notch1 transcription complexes, inhibited recruitment of Notch1 to the NTC (Notch Ternary Complex) and to the HES1 promoter, and reduced Notch1 recruitment to target genes.
NADI-351 inhibits tumor growth in Notch-dependent cancers and does not exert gastrointestinal toxicity associated with goblet cell metaplasia.
NADI-351 selectively inhibits stem-like esophageal adenocarcinoma (EAC) cell populations.
| M.Wt | 465.518 | |
| Formula | C19H20FN5O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-2-(5-(1-(4-((4H-1,2,4-triazol-3-yl)methoxy)-3-fluoro-5-methoxyphenyl)ethylidene)-4-oxo-2-thioxothiazolidin-3-yl)-N,N-dimethylacetamide |
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1. Annamil Alvarez-Trotta, et al. Cancer Res. 2021 Jun 15;81(12):3347-3357.
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