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Chemical Structure : NBD-11021
Catalog No.: PC-70010Not For Human Use, Lab Use Only.
A small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction.
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A small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction; inhibits the CD4-dependent virus in a dose-dependent manner with IC50 of 2.4 uM; also weakly shows HIV-1 RT inhibition with IC50 of 43.4 uM; exhibits pan-neutralization activity against a panel of 56 Env-pseudotyped HIV-1 representing diverse subtypes of clinical isolates (IC50 as low as 270 nM).
HIV
Preclinical
| M.Wt | 444.978 | |
| Formula | C22H25ClN4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Curreli F, et al. J Med Chem. 2015 Sep 10;58(17):6909-6927.
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