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Chemical Structure : NC-043
Catalog No.: PC-61798Not For Human Use, Lab Use Only.
NC-043 (15-Oxospiramilactone) is a diterpenoid derivative inhibitor of Wnt/β-catenin signaling that interferes with the β-catenin/TCF4 association.
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NC-043 (15-Oxospiramilactone) is a diterpenoid derivative inhibitor of Wnt/β-catenin signaling that interferes with the β-catenin/TCF4 association.
NC-043 decreases the mRNA and/or protein expression of Wnt target genes Axin2, Cyclin D1 and Survivin in SW480 cells, inhibits anchorage-independent growth and xenograft tumorigenesis in vitro and in vivo.
NC-043 inhibits canonical Wnt signaling downstream of β-catenin stability, causes G2/M arrest and inhibits colon cancer cell growth.
| M.Wt | 330.42 | |
| Formula | C20H26O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang W, et al. Cell Res. 2011 May;21(5):730-40.
2. Yan M, et al. Exp Biol Med (Maywood). 2017 Jun;242(11):1185-1197.
3. He X, et al. Cell Discov. 2017 Jan 31;3:17003.
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