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NCB-0846

Chemical Structure NCB-0846

CAS No.: 1792999-26-8

NCB-0846 (NCB 0846;NCB0846)

Catalog No.: PC-42270Not For Human Use, Lab Use Only.

The first orally available, small-molecule TNIK inhibitor with IC50 of 21 nM.

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10 mg $156 In stock
25 mg $316 In stock
50 mg $544 In stock
100 mg $960 In stock
500 mg Get quote

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

The first orally available, small-molecule TNIK inhibitor with IC50 of 21 nM; also weakly inhibits FLT3, JAK3, PDGFRα, TRKA, CDK2/CycA2, and HGK (IC80>0.1 uM); induces faster migration of TCF4 phosphorylated by TNIK at 0.1-0.3 uM, and completely inhibits at 3 uM; also reduces the expression of TNIK, AXIN2, cMYC, LRP6 and LRP5; abrogates colorectal cancer stemness, suppresses Wnt-driven intestinal tumorigenesis in Apc(min/+) mice.

Colon Cancer

Preclinical

Physicochemical Properties

M.Wt 375.4237
Formula C21H21N5O2
CAS No. 1792999-26-8
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 1 Month
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name

Cyclohexanol, 4-[[2-(1H-benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-, cis-

Clinical Information

References

1. Masuda M, et al. Nat Commun. 2016 Aug 26;7:12586.

2. Yamada T, et al. Cancer Sci. 2017 May;108(5):818-823.

3. Mahmoudi T, et al. EMBO J. 2009 Nov 4;28(21):3329-40.

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