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Chemical Structure : NCD-38
Catalog No.: PC-61955Not For Human Use, Lab Use Only.
NCD-38 is a novel potent, selective LSD1 inhibitor with IC50 of 0.59 uM, exerts highly selective inhibitory activity on LSD1 but no other enzymes, such as MAO (IC50>100 uM).
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NCD-38 is a novel potent, selective LSD1 inhibitor with IC50 of 0.59 uM, exerts highly selective inhibitory activity on LSD1 but no other enzymes, such as MAO (IC50>100 uM).
NCD-38 inhibits the growth of MLL-AF9 leukemia as well as erythroleukemia, megakaryoblastic leukemia and myelodysplastic syndromes (MDSs) overt leukemia cells.
| M.Wt | 680.165 | |
| Formula | C37H37ClF3N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Miyamura S, et al. Org Biomol Chem. 2016 Sep 28;14(36):8576-85.
2. Sugino N, et al. Leukemia. 2017 Nov;31(11):2303-2314.
3. Ogasawara D, et al. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8620-4.
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