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Chemical Structure : NCGC00161856
Catalog No.: PC-20499Not For Human Use, Lab Use Only.
NCGC00161856 is the first small-molecule ligand and inverse agonist of TSHR, inhibits basal cAMP production by TSHR in HEK-EM 293 cells stably expressing TSHRs with IC50 of 3.0 uM.
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NCGC00161856 is the first small-molecule ligand and inverse agonist of TSHR, inhibits basal cAMP production by TSHR in HEK-EM 293 cells stably expressing TSHRs with IC50 of 3.0 uM.
NCGC00161856 also inhibits TSH-stimulated cAMP production with IC50 of 0.78 uM.
NCGC00161856 is a competitive antagonist of TSH-stimulated signaling.
NCGC00161856 (30 uM) inhibits the basal expression of mRNAs for TPO, TSHR, TG, NIS, and DIO2 in primary cultures of human thyrocytes.
| M.Wt | 468.55 | |
| Formula | C29H28N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Neumann S, et al. Endocrinology 151:3454–3459.
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