Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NCGC00229600
CAS No.: 1338824-20-6
Catalog No.: PC-20501Not For Human Use, Lab Use Only.
NCGC00229600 is a small molecule, allosteric inverse agonist of TSH receptor (TSHR), inhibits basal cAMP production by TSHRs by 53% at 30 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $268 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $758 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
NCGC00229600 is a small molecule, allosteric inverse agonist of TSH receptor (TSHR), inhibits basal cAMP production by TSHRs by 53% at 30 uM.
NCGC00229600 shows no effect on [125I]TSH binding to HEKTSHR cells, no effect on the binding of two monoclonal anti-TSHR antibodies, 2C11 and 4C1.
NCGC00229600 is an antagonist of basal and hTSH stimulation of hTSHR in human cells.
NCGC00229600 inhibits TSHR-mediated basal and GD sera up-regulation of thyroperoxidase mRNA levels by 65 ± 2.0% in primary cultures of human thyrocytes.
| M.Wt | 479.58 | |
| Formula | C30H29N3O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
O=C1N(CC2=CC=CN=C2)C(C3=CC=C(OC)C(COC4=C(C)C=CC=C4C)=C3)NC5=C1C=CC=C5 |
|
1. Susanne Neumann, et al. J Clin Endocrinol Metab. 2011 Feb;96(2):548-54.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
