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Chemical Structure : NCGC00262650
CAS No.: 344359-25-7
Catalog No.: PC-38537Not For Human Use, Lab Use Only.
NCGC00262650 is a small molecule merozoite invasion inhibitor inhibitor of parasite AMA1-RON2 interaction, blocks entry of merozoites into RBCs with IC50 of 9.8 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $348 | In stock | |
| 100 mg | $858 | In stock | |
| 1 g | Get quote |
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NCGC00262650 is a small molecule merozoite invasion inhibitor inhibitor of parasite AMA1-RON2 interaction, blocks entry of merozoites into RBCs with IC50 of 9.8 uM.
NCGC00262650 exhibits no effect on intracellular growth and merozoite rupture from schizonts.
NCGC00262650 enhances the efficiency of growth inhibition in combination with Artemisinin.
NCGC00262650 blocks merozoite invasion by binding AMA1.
NCGC00262650 disrupts the function of AMA1-RON2 interaction, namely junction formation, a crucial step in merozoite invasion of RBCs.
| M.Wt | 308.385 | |
| Formula | C18H20N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-Cyclopentyl-5-(4-methoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine |
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1. Prakash Srinivasan, et al. Nat Commun. 2013;4:2261. doi: 10.1038/ncomms3261.
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