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Chemical Structure : NCT-502
CAS No.: 1542213-00-2
Catalog No.: PC-62265Not For Human Use, Lab Use Only.
NCT-502 is a small molecule 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3.7 uM) that reduces the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $388 | In stock | |
| 100 mg | Get quote |
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NCT-502 is a small molecule 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3.7 uM) that reduces the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells.
NCT-502 decreases intracellular serine and glycine concentrations in MDA-MB-231 cells.
NCT-502 also reduces the PSAT1-catalyzed production of M+5-α-ketoglutarate.
| M.Wt | 395.448 | |
| Formula | C18H20F3N5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(4,6-dimethyl-2-pyridinyl)-4-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarbothioamide |
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1. Pacold ME, et al. Nat Chem Biol. 2016 Jun;12(6):452-8.
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