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Chemical Structure : ND-378
Catalog No.: PC-60174Not For Human Use, Lab Use Only.
ND-378 (ND378) is a potent, selective MMP-2 inhibitor with Ki of 230 nM.
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ND-378 (ND378) is a potent, selective MMP-2 inhibitor with Ki of 230 nM.
ND-378 does not inhibit the closely related MMP-9 or MMP-14, and other MMPs (Ki>50 uM).
ND-378 can cross the blood-spinal cord barrier, achieving therapeutic concentrations in the injured spinal cord, shows no change in long-term neurological outcomes in mice.
| M.Wt | 377.473 | |
| Formula | C18H19NO4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gao M, et al. ACS Chem Neurosci. 2016 Nov 16;7(11):1482-1487.
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