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Chemical Structure : ND2158
Catalog No.: PC-38157Not For Human Use, Lab Use Only.
ND2158 (ND-2158) is a highly potent and selective IRAK4 inhibitor with IC50 of 1.3 nM.
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ND2158 (ND-2158) is a highly potent and selective IRAK4 inhibitor with IC50 of 1.3 nM.
ND2158 demonstrates high selectivity against 334 kinases, and >1000-fold over IRAK1.
ND2158 blocked TNF production, collagen-induced arthritis, and gout formation in mice, suppressed LPS-induced TNF production, alleviated collagen-induced arthritis, and blocked gout formation in mouse models.
IRAK4 inhibition promoted killing of ABC DLBCL lines harboring MYD88 L265P, by down-modulating survival signals, including NF-κB and autocrine IL-6/IL-10 engagement of the JAK-STAT3 pathway.
In ABC DLBCL xenograft models, IRAK4 inhibition suppressed tumor growth as a single agent, and in combination with the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib or the Bcl-2 inhibitor ABT-199.
| M.Wt | 446.566 | |
| Formula | C22H30N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Priscilla N Kelly, et al. J Exp Med. 2015 Dec 14;212(13):2189-201.
2. Giménez N, et al. Leukemia. 2020 Jan;34(1):100-114.
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