NDT-30805 | NLRP3 inhibitor | Probechem Biochemicals

Chemical Structure : NDT-30805

Catalog No.: PC-49268Not For Human Use, Lab Use Only.

NDT-30805 is a potent and selective small molecule NLRP3 inflammasome inhibitor with IC50 of 13 nM for IL-1β inhibition in PBMCs.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NDT-30805 is a potent and selective small molecule NLRP3 inflammasome inhibitor with IC50 of 13 nM for IL-1β inhibition in PBMCs.

M.Wt	414.531
Formula	C23H22N6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino)-5-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidine-7(4H)-thione

1. David Harrison, et al. ACS Med Chem Lett. 2022 Aug 1;13(8):1321-1328.