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Chemical Structure : NFX-179
Catalog No.: PC-21237Not For Human Use, Lab Use Only.
NFX-179 (Nedometinib, NFX179) is a potent, specific, topical, metabolically labile MEK1/2 inhibitor with biochemical IC50 of 135 nM (MEK1).
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NFX-179 (Nedometinib, NFX179) is a potent, specific, topical, metabolically labile MEK1/2 inhibitor with biochemical IC50 of 135 nM (MEK1).
NFX-179 is specific for MEK1 inhibition and does not have substantial interactions across a panel of more than 150 kinases or a separate panel of 44 targets of particular relevance for neurological or cardiac toxicity.
NFX-179 potently inhibits phosphorylated-ERK (p-ERK) expression in a malignant peripheral nerve sheath tumor cell line HCT116 (KRAS-mutant G13D) and A375 (BRAF-mutant V600E) with IC50 of 164 nM and 12 nM, respectively.
NFX-179 gel (topical application) significantly reduced the formation of new cSCCs in ultraviolet-induced cSCC mouse models.
NFX-179 inhibits the growth of human SCC cell lines in a dose-dependent manner, and topical NFX-179 application penetrates human skin and inhibits MAPK signaling in human cutaneous squamous cell carcinoma (cSCC) explants.
| M.Wt | 470.24 | |
| Formula | C17H16FIN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sarin KY, et al. Sci Transl Med. 2023 Oct 11;15(717):eade1844.
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