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Chemical Structure : NGD-94-1
Catalog No.: PC-21488Not For Human Use, Lab Use Only.
NGD-94-1 is a highly potent, selective dopamine D4 receptor antagonist with Ki of 3.6 nM.
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NGD-94-1 is a highly potent, selective dopamine D4 receptor antagonist with Ki of 3.6 nM.
NGD-94-1 displays 600-fold selectivity for the D4.2 receptor subtype compared with a wide variety of monoamine or other neurotransmitter receptor or modulatory sites except for 5-HT1A and 5-HT3 receptors.
NGD 94-1 completely reverses the decrease in forskolin-stimulated cAMP levels produced by the dopamine receptor full agonist quinpirole.
NGD-94-1 behaves as an agonist in human embryonic kidney 293 cells expressing human recombinant dopamine D4.4 receptors.
| M.Wt | 320.40 | |
| Formula | C18H20N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gazi L, et al. Eur J Pharmacol. 1999 May 21;372(3):R9-10.
2. Tallman JF, et al. J Pharmacol Exp Ther. 1997 Aug;282(2):1011-9.
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