Chemical Structure : NGD94-1
CAS No.:
178928-68-2
NGD94-1
(NGD 94-1)
Catalog No.: PC-27156Not For Human Use, Lab Use Only.
NGD94-1 (NGD 94-1) is a potent and selective dopamine D4 receptor (D4R) antagonist with Ki of 3.6 nM for cloned human D4.2 receptor.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NGD94-1 (NGD 94-1) is a potent and selective dopamine D4 receptor (D4R) antagonist with Ki of 3.6 nM for cloned human D4.2 receptor.
NGD94-1 (NGD 94-1) displays >600-fold selectivity for D4.2 receptor subtype compared with a wide variety of monoamine or other neurotransmitter receptor or modulatory sites except for 5-HT1A and 5-HT3 receptors.
NGD94-1 (NGD 94-1) is also an agonist in human embryonic kidney 293 cells expressing human recombinant dopamine D4.4 receptors.
NGD 94-1 completely reversed the decrease in forskolin-stimulated cAMP levels produced by the dopamine receptor full agonist quinpirole.
NGD94-1 (NGD 94-1) reverses subchronic phencyclidine-induced object retrieval/detour deficits in vivo.
Physicochemical Properties
|
M.Wt
|
320.40
|
|
Formula
|
C18H20N6
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
2-(4-((2-Phenyl-1H-imidazol-5-yl)methyl)piperazin-1-yl)pyrimidine
|
References
1. J D Jentsch, et al. Psychopharmacology (Berl). 1999 Feb;142(1):78-84.
2. Gazi L, et al. Eur J Pharmacol. 1999 May 21;372(3):R9-10.
3. Tallman JF, et al. J Pharmacol Exp Ther. 1997 Aug;282(2):1011-9.
Contact Us
sales@probechem.com
