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Chemical Structure : NH-23-C2
Catalog No.: PC-72960Not For Human Use, Lab Use Only.
NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8.
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NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8.
NH-23-C2 displays off-reactivity with cysteine and threonine proteases (cathepsins B, L, V, S).
HCT116 cells were preincubated with NH-23-C2 inhibitor, MDM-2 cleavage was inhibited in a concentration-dependent manner (IC50 =3.11 μM).
NH-23-C2 selectively block caspase-2 activity and caspase-2-mediated MDM-2 cleavage.
| M.Wt | 845.903 | |
| Formula | C43H51N5O13 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Marcin Poreba, et al. Cell Death Differ. 2019 Dec;26(12):2695-2709.
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