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Chemical Structure : NIBR189
CAS No.: 1599432-08-2
Catalog No.: PC-42985Not For Human Use, Lab Use Only.
NIBR189 is a potent and selective EBI2 (GPR183) antagonist with IC50 of 11 and 15 nM for hEBI2 and mEBI2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 100 mg | $688 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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NIBR189 is a potent and selective EBI2 (GPR183) antagonist with IC50 of 11 and 15 nM for hEBI2 and mEBI2, respectively.
NIBR189 does not show any activity against a panel of other GPCRs, transporters, and enzymes at 30 uM.
NIBR189 blocks oxysterol-dependent activation with IC50 of 9 nM, inhibits cell migration of U937 cells with IC50 of 0.3 nM.
NIBR189 inhibits LPS-stimulated mouse astrocytes induceed macrophage migration, inhibits the effects of 7α25HC in human astrocytes.
| M.Wt | 429.307 | |
| Formula | C21H21BrN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 47 mg/mL |
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| Chemical Name/SMILES |
2-Propen-1-one, 3-(4-bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-, (2E)- |
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1. Gessier F, et al. J Med Chem. 2014 Apr 24;57(8):3358-68.
2. Rutkowska A, et al. Sci Rep. 2016 May 11;6:25520.
3. Rutkowska A, et al. Neuropharmacology. 2018 May 1;133:121-128.
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