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Chemical Structure : NIC7
Catalog No.: PC-49463Not For Human Use, Lab Use Only.
NLRP3-inhibitory compound 7 (NIC7) is a small-molecule inhibitor of Nod-like receptor family pyrin domain-containing 3 (NLRP3), inhibits NLRP3-mediated activation of caspase 1 along with the secretion of IL-1β, IL-18, and lactate dehydrogenase.
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NLRP3-inhibitory compound 7 (NIC7) is a small-molecule inhibitor of Nod-like receptor family pyrin domain-containing 3 (NLRP3), inhibits NLRP3-mediated activation of caspase 1 along with the secretion of IL-1β, IL-18, and lactate dehydrogenase.
NIC7 significantly reversed the associated disease symptoms in the mice Alzheimer's disease (AD) model.
NIC7 did not reverse the disease symptoms in the imiquimod (IMQ)-induced disease model of psoriasis.
| M.Wt | 480.557 | |
| Formula | C23H20N4O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Muhammad Haseeb, et al. ACS Chem Neurosci. 2022 Mar 16;13(6):818-833.
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