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Chemical Structure : NJNU-0069-003
Catalog No.: PC-20892Not For Human Use, Lab Use Only.
NJNU-0069-003 is a specific small-molecule inducer of major histocompatibility complex class II (MHC-II), directly binds to the MAT domain of FASN with Kd of 7.98 uM.
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NJNU-0069-003 is a specific small-molecule inducer of major histocompatibility complex class II (MHC-II), directly binds to the MAT domain of FASN with Kd of 7.98 uM.
NJNU-0069-003 increases the expression of MHC-II genes, dose-dependently upregulates the surface MHC-II protein levels in 4T1 mouse cancer cells and human cancer cells including MCF-7 and Hs578T.
NJNU-0069-003 cannot upregulate the expression of IFN-γ responsive genes and was unable to activate the JAK/STAT signaling pathway.
NJNU-0069-003 (100 mg/kg for four times every other day) can effectively inhibit the growth on Balb/c mice bearing 4T1 tumors, fires up the tumor microenvironment by promoting immune detection.
| M.Wt | 515.78 | |
| Formula | C32H53NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ling Huang, et al. Cell Chem Biol. 2023 May 22;S2451-9456(23)00126-5.
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