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Chemical Structure : NK1-IN-9
Catalog No.: PC-60173Not For Human Use, Lab Use Only.
A potent, orally active, dual NK1 receptor antagonist (IC50=0.5 nM) and SERT inhibitor (IC50=5.2 nM).
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A potent, orally active, dual NK1 receptor antagonist (IC50=0.5 nM) and SERT inhibitor (IC50=5.2 nM); demonstrates favorable oral bioavailability, excellent brain uptake, and robust in vivo efficacy in a validated depression model.
| M.Wt | 436.352 | |
| Formula | C22H24Cl2FN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Degnan AP, et al. ACS Chem Neurosci. 2016 Dec 21;7(12):1635-1640.
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