NKT2152 | HIF-2α inhibitor | Probechem Biochemicals

Chemical Structure : NKT2152

NKT2152 (Imdatifan)

Catalog No.: PC-27306Not For Human Use, Lab Use Only.

NKT2152 (Imdatifan) is a potent, selective, and orally available HIF-2alpha (HIF-2α) inhibitor with IC50 of 6.0 nM, disrupts the HIF-2α/HIF-1β complex, selectively suppressing target gene expression in VHL-deficient 786-O ccRCC cells.

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Biological Activity

Physicochemical Properties

M.Wt	385.27
Formula	C18H9F6NO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile

References

1. Fu J, et al. ACS Med Chem Lett. 2026 Jun 4;17(7):1590-1600.

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NKT2152 (Imdatifan)

Biological Activity

Physicochemical Properties

References

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