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NLRP3-IN-3

Chemical Structure : NLRP3-IN-3

CAS No.: 2254433-37-7

NLRP3-IN-3

Catalog No.: PC-73216Not For Human Use, Lab Use Only.

NLRP3-IN-3 is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of 1.26 nM in THP1 cells, showing good pharmacokinetic profiles with oral bioavailability.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NLRP3-IN-3 is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of 1.26 nM in THP1 cells, showing good pharmacokinetic profiles with oral bioavailability.

Physicochemical Properties

M.Wt 439.534
Formula C22H25N5O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

1. Sharma R., Iyer P., Agarwal S. Novel Substituted Sulfoximine Compounds. WO/2018/225018.

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