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Chemical Structure : NMS-P118
CAS No.: 1262417-51-5
Catalog No.: PC-45571Not For Human Use, Lab Use Only.
NMS-P118 is a potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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NMS-P118 is a potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2.
NMS-P118 exhibits excellent ADME and pharmacokinetic profiles and high efficacy in MDA-MB-436 and Capan-1 xenograft models; orally available.
| M.Wt | 395.4187 | |
| Formula | C20H24F3N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 16 mg/mL |
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| Chemical Name/SMILES |
1H-Isoindole-4-carboxamide, 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo- |
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1. Papeo G, et al. J Med Chem. 2015 Sep 10;58(17):6875-98.
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