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Chemical Structure : NMS-P293
Catalog No.: PC-61976Not For Human Use, Lab Use Only.
NMS-P293 is a novel potent and selective PARP-1 inhibitor possessing >200-fold selectivity versus PARP-2.
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NMS-P293 is a novel potent and selective PARP-1 inhibitor possessing >200-fold selectivity versus PARP-2; NMS-P293 inhibits hydrogen peroxide induced poly ADP-ribose (PAR) synthesis with an IC50 in the single digit nanomolar range; possesses favorable ADME properties, causes complete tumor regressions in mice bearing BRCA mutated breast cancer xenografts.
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| Appearance | Solid | |
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10 mM in DMSO |
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