Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NNC 05-2090 hydrochloride
Catalog No.: PC-62929Not For Human Use, Lab Use Only.
NNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
NNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM.
NNC 05-2090 displays >10 fold selectivity over mGAT1, mGAT3 and mGAT4, also has alpha 1- and D2-receptor affinity of 266 and 1632 nM, respectively.
NNC 05-2090 inhibits 3HGABA uptake into synaptosomes from cerebral cortex with IC50 of 4.4 uM.
NNC 05-2090 significantly reduces generalized seizure severity and afterdischarge duration in rats.
| M.Wt | 451.01 | |
| Formula | C27H31ClN2O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Thomsen C, et al. Br J Pharmacol. 1997 Mar;120(6):983-5.
2. Dalby NO, et al. Epilepsy Res. 1997 Jul;28(1):51-61.
3. Jinzenji A, et al. J Pharmacol Sci. 2014;125(2):217-26.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
