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Chemical Structure : NNC 55-0396
CAS No.: 357400-13-6
Catalog No.: PC-45854Not For Human Use, Lab Use Only.
NNC 55-0396 is a potent and selective T-type calcium channel antagonist that blocks recombinant alpha(1)G T-type channels in human embryonic kidney 293 cellswith IC50 of 7 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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NNC 55-0396 is a potent and selective T-type calcium channel antagonist that blocks recombinant alpha(1)G T-type channels in human embryonic kidney 293 cellswith IC50 of 7 uM.
NNC 55-0396 has no detectable effect on high-voltage-activated channels in INS-1 cells.
NNC 55-0396 inhibits MCF-7 (ERalpha+) cellular proliferation, inhibits tumor-induced angiogenesis in vitro and in vivo by suppressing HIF-1α stability.
NNC 55-0396 significantly suppresses glioblastoma tumor growth in a xenograft model.
NNC 55-0396 is a small molecule inhibitor of the PEX3-PEX19 interaction, effectively disrupts PEX3-PEX19 interaction at 4 μM.
NNC 55-0396 shows anti-tumoral effect, which is dependent on peroxisomal functions, but not on T-type calcium channels (TTCCs).
NNC 55-0396 shows anti-tumor response with MAPK-targeted therapy in melanoma.
| M.Wt | 564.5619 | |
| Formula | C30H40Cl2FN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO |
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| Chemical Name/SMILES |
Cyclopropanecarboxylic acid, (1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, hydrochloride (1:2) |
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