NOX5-IN-1

Chemical Structure : NOX5-IN-1

Catalog No.: PC-28571Not For Human Use, Lab Use Only.

NOX5-IN-1 (Compound 13) is a potent, selective NADPH oxidase 5 (NOX5) inhibitor with IC50 of 0.3 uM in cell-free assays, shows no activity against NOX1, NOX2 , NOX4, NOX5 and DUOX1 (IC50>10 uM).

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Biological Activity

NOX5-IN-1 (Compound 13) is a potent, selective NADPH oxidase 5 (NOX5) inhibitor with IC50 of 0.3 uM in cell-free assays, shows no activity against NOX1, NOX2 , NOX4, NOX5 and DUOX1 (IC50>10 uM).
NOX5-IN-1 (0.05-15 uM) inhibit NOX5-dependent production of ROS in Freestyle293 cells overexpressing functional human NOX5.

Physicochemical Properties

M.Wt	402.48
Formula	C21H18N6OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3H-1,2,3-Triazolo[4,5-d]pyrimidine, 7-[[6-(1-methylethyl)-2-benzoxazolyl]thio]-3-(phenylmethyl)-

References

1. Blessing C Ogboo, et al. J Med Chem. 2025 Jul 10;68(13):14072-14084.

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NOX5-IN-1

Biological Activity

Physicochemical Properties

References

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