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Chemical Structure : NP3-562
Catalog No.: PC-21638Not For Human Use, Lab Use Only.
NP3-562 is a potent, orally bioavailable NLRP3 inflammasome inhibitor, inhibits IL-1β in nigericin-stimulated THP-1 cells with IC50 of 90 nM.
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NP3-562 is a potent, orally bioavailable NLRP3 inflammasome inhibitor, inhibits IL-1β in nigericin-stimulated THP-1 cells with IC50 of 90 nM.
NP3-562 potently inhibits IL-1β in human whole blood after LPS/ATP stimulation with IC50 of 214 nM, and IC50 of 248 nM for mouse whole blood stimulated with LPS/ATP.
NP3-562 binds to the NLRP3 NACHT domain with IC50 of 0.26 uM in FP binding assays, shows a unique binding mode as compared to the known sulfonylurea-based inhibitors.
NP3-562 (50 mg/kg po) caused 90% IL-1β inhibition at 1.68 ± 0.53 μM blood concentration in female C57BL/6 mice.
NP3-562 shows a clean off-target profile, including no mutagenic findings, no interference with the NF-κB pathway (TNFα IC50>100 μM).
| M.Wt | 437.94 | |
| Formula | C19H24ClN5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Juraj Velcicky, et al. J Med Chem. 2024 Jan 4. doi: 10.1021/acs.jmedchem.3c02098.
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