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Chemical Structure : NP627
Catalog No.: PC-73059Not For Human Use, Lab Use Only.
NP627 (NP-627) is a specific small-molecule inhibitor of protein kinase C deltaI (PKCδI) with Kd of 1 nM.
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NP627 (NP-627) is a specific small-molecule inhibitor of protein kinase C deltaI (PKCδI) with Kd of 1 nM.
NP627 inhibits the cleavage of PKCδI in adipocyte (at 10 nM) and decreases PKCδI kinase activity.
NP627 does not inhibit other PKC isozyme activities.
NP627 prevents caspase-3 mediated cleavage of PKCδI, significantly inhibits PKCδI catalytic fragment release, decreases inflammation and apoptosis, and significantly improves mitochondrial metabolism in human adipocytes from obese individuals.
| M.Wt | 560.571 | |
| Formula | C27H28N8O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sparks RP, et al. J Biol Chem. 2019 Oct 11;294(41):14896-14910.
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