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Chemical Structure : NPS-2143
CAS No.: 284035-33-2
Catalog No.: PC-42051Not For Human Use, Lab Use Only.
NPS-2143 (SB262470) is a potent, selective and orally active CaSR antagonist with IC50 of 43 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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NPS-2143 (SB262470) is a potent, selective and orally active CaSR antagonist with IC50 of 43 nM.
NPS-2143 (SB262470) does not inhibit cytoplasmic Ca2+ responses to glutamate in HEK 293 cells engineered to express mGluRs and GABAB receptors.
NPS-2143 (SB262470) stimulates parathyroid hormone (PTH ) secretion from bovine parathyroid cells in vitro (EC50=39 nM) and increases plasma PTH levels in vivo.
NPS-2143 (SB262470) also inhibits lipopolysaccharide-induced pulmonary inflammation.
| M.Wt | 408.9205 | |
| Formula | C24H25ClN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzonitrile, 2-chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]- |
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1. Gowen M, et al. J Clin Invest. 2000 Jun;105(11):1595-604.
2. Nemeth EF, et al. J Pharmacol Exp Ther. 2001 Oct;299(1):323-31.
3. Lee JW, et al. Mol Immunol. 2017 Oct;90:150-157.
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