NRL-1049 ((R)-BA1049) | ROCK2 inhibitor

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Chemical Structure : NRL-1049

CAS No.: 1973494-16-4

NRL-1049 ((R)-BA1049, NRL1049)

Catalog No.: PC-20084Not For Human Use, Lab Use Only.

NRL-1049 ((R)-BA-1049) is a potent, orally-available ROCK2-selective inhibitor with IC50 of 0.24 uM, 16-fold selectivity over ROCK-1.

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10 mg	$218	In stock
25 mg	$378	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NRL-1049 ((R)-BA-1049) is a potent, orally-available ROCK2-selective inhibitor with IC50 of 0.24 uM, 16-fold selectivity over ROCK-1.
Neither BA-1049 nor the metabolite inhibits PKA or PKC at physiological ATP concentrations.
BA-1049 is a promising drug candidate to reduce lesion growth and hemorrhage in both CCM1 and CCM3 models of cavernous angioma (CA).

Physicochemical Properties

M.Wt	319.42
Formula	C16H21N3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(1-(isoquinolin-5-ylsulfonyl)piperidin-4-yl)ethan-1-amine

References

1. Lisa McKerracher, et al. Transl Stroke Res. 2020 Jun;11(3):365-376.

2. Patent US20170313680A1.

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NRL-1049 ((R)-BA1049, NRL1049)

Biological Activity

Physicochemical Properties

References

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