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Chemical Structure : NRPa-308
Catalog No.: PC-21447Not For Human Use, Lab Use Only.
NRPa-308 is a neuropilin-1 (NRP-1) antagonist, inhibits the VEGF-A165/NRP-1 binding with IC50 of 42 uM, exerts in vitro anti-angiogenic activity.
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NRPa-308 is a small molecule neuropilin-1 (NRP-1) antagonist, inhibits the VEGF-A165/NRP-1 binding with IC50 of 42 uM, exerts in vitro anti-angiogenic activity.
NRPa-308 exhibits cellular activity with IC50 of 0.5 uM on a human aggressive and metastatic estrogenR−/progesteroneR−/Her2- breast cancer cell line (MDA-MB-231).
NRPa-308 dramatically inhibits tubulogenesis for HUVEC tubule formation in a collagen gel under VEGF-A165 stimulation.
NRPa-308 (50 mg/kg) improves the median survival and reduces the tumour growth on mice xenografted with human breast cancer cells (MDA-MB-231), does not exert visible acute toxicity.
| M.Wt | 424.52 | |
| Formula | C23H24N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang-Qing Liu, et al. Cancer Lett. 2018 Feb 1:414:88-98.
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