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Chemical Structure : NSC109555 ditosylate
Catalog No.: PC-60282Not For Human Use, Lab Use Only.
NSC109555 ditosylate (DDUG) is a potent, selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 uM.
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NSC109555 ditosylate (DDUG) is a potent, selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 uM.
NSC109555 displays no effect on a range of other kinases including Chk1 (IC50>10 uM).
NSC109555 inhibits histone H1 phosphorylation (IC50=0.24 uM) and attenuates mitochondrial ATP synthesis.
NSC109555 exhibits antiproliferative activity in a number of leukemias in vivo.
| M.Wt | 752.86 | |
| Formula | C19H24N10O.2C7H8O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jobson AG, et al. Mol Pharmacol. 2007 Oct; 72(4):876-84.
2. Gogineni VR, et al. Cancer Lett. 2011 Dec 26;313(1):64-75.
3. Mikles-Robertson F, et al. Cancer Res. 1980 Apr;40(4):1054-61.
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