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Chemical Structure : NSC13728
Catalog No.: PC-20798Not For Human Use, Lab Use Only.
NSC13728 is a specific small molecule stabilizer of the Max homodimer inhibiting Myc function, also inhibits Myc-Max heterodimerization.
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NSC13728 is a specific small molecule stabilizer of the Max homodimer inhibiting Myc function, also inhibits Myc-Max heterodimerization.
NSC13728 does not significantly enhance DNA binding of the Myc-Max heterodimer or of the Max homodimer, as determined by EMSA analysis.
NSC13728 reduces the association of Myc with Max in a dose-dependent manner in MCF7-35IM cells.
NSC13728 inhibited the Myc-induced formation of transformed cell foci in CEF and growth inhibition in Q8 cells with IC50 of 3 uM.
NSC13728 inhibits growth and complements growth reduction by ICI 182,780 in MCF7-35IM cells.
| M.Wt | 464.66 | |
| Formula | C31H36N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hao Jiang, et al. Mol Pharmacol. 2009 Sep;76(3):491-502.
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