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Chemical Structure : NSC 19630
CAS No.: 72835-26-8
Catalog No.: PC-61921Not For Human Use, Lab Use Only.
NSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20 uM.
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|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | $298 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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NSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20 uM.
NSC 19630 (MIRA-1) shows selecitvity over human RecQ helicases (RECQ1 and BLM), Fanconi anemia group J (FANCJ) helicases and three Escherichia coli helicases (RecQ, UvrD, and DnaB).
NSC 19630 (MIRA-1) dramatically impaires growth and proliferation, induces apoptosis in a WRN-dependent manner, and resultes in elevated γ-H2AX and PCNA foci in human cells.
NSC 19630 (MIRA-1) delays S-phase progression and induces DNA damage;.
NSC 19630 (MIRA-1) is a mutant p53 reactivator that induces mutant p53-dependent cell death in different human tumor cells carrying tetracycline-regulated mutant p53.
| M.Wt | 183.2 | |
| Formula | C8H9NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-[(1-oxopropoxy)methyl]-1H-pyrrole-2,5-dione |
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1. Aggarwal M, et al. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1525-30.
2. Saha MN, et al. Br J Cancer. 2014 Apr 29;110(9):2224-31.
3. Bykov VJ, et al. J Biol Chem. 2005 Aug 26;280(34):30384-91.
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