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NSC 23766

Chemical Structure : NSC 23766

CAS No.: 733767-34-5

NSC 23766 (NSC-23766;NSC23766)

Catalog No.: PC-44660Not For Human Use, Lab Use Only.

NSC 23766 (NSC23766) is a specific small molecule inhibitor of Rac GTPase.

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Biological Activity

NSC 23766 (NSC23766) is a specific small molecule inhibitor of Rac GTPase.
NSC 23766 potently blockes serum or PDGF-induced Rac1 activation and lamellipodia formation without affecting the activity of endogenous Cdc42 or RhoA.
NSC 23766 inhibits the proliferation, anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.

Physicochemical Properties

M.Wt 421.5816
Formula C24H35N7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4,6-Quinolinediamine, N6-[2-[[4-(diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-

References

1. Gao Y, et al. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7618-23.

2. Barros P, et al. Mol Cell Biol. 2009 Aug;29(15):4156-66.

3. Yoshida T, et al. Mol Cancer Ther. 2010 Jun;9(6):1657-68.

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