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Chemical Structure : NSC290956
Catalog No.: PC-72832Not For Human Use, Lab Use Only.
NSC290956 is a small molecule inhibitor of KRas with Kd of 21.3 uM.
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NSC290956 is a small molecule inhibitor of KRas with Kd of 21.3 uM.
NSC290956 inhibits KRas activity and downstream signaling events in KRas-driven nuytant NSCLC cells, decreases the cellular viability, cell cycle, and migration.
NSC290956 changes KRas-dependent metabolic phenotype in Non-small-cell lung cancer cells, regulates mitochondrial dysfunction for apoptosis in both A549 and H358 cells.
NSC290956 shows activity in the KRas mutant cell line xenograft.
| M.Wt | 446.024 | |
| Formula | C22H24ClN3OS2 | |
| Appearance | Solid | |
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1. Jiaxin Zhang, et al. Front Pharmacol. 2022 Jan 5;12:797821.
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