NSC37215 | TREX1 inhibitor | Probechem Biochemicals

Chemical Structure : NSC37215

NSC37215 (NSC 37215)

Catalog No.: PC-26961Not For Human Use, Lab Use Only.

NSC37215 is an effective small molecule inhibitor of three prime repair exonuclease 1 (TREX1) with IC50 of 4.72 uM and 30.32 uM for human and mouse TREX1 respectively.

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Biological Activity

NSC37215 is an effective small molecule inhibitor of three prime repair exonuclease 1 (TREX1) with IC50 of 4.72 uM and 30.32 uM for human and mouse TREX1 respectively.
NSC37215 exhibits a lower Kd with hTREX1 than that with mTREX1.
NSC37215 inhibits mTREX1 in binding DNA in EMSA assays, inhibits the nuclease activity of TREX1 by interfering with DNA binding.

Physicochemical Properties

M.Wt	484.46
Formula	C24H17N2NaO6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Naphthalenesulfonic acid, 7-[[4-(benzoylamino)benzoyl]amino]-4-hydroxy-, sodium salt

References

1. Xing C, et al. Cancer Res. 2025 Aug 1;85(15):2858-2875.

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NSC37215 (NSC 37215)

Biological Activity

Physicochemical Properties

References

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