Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NSC 658497
Catalog No.: PC-62490Not For Human Use, Lab Use Only.
NSC 658497 is a small molecule inhibitor of Ras GEF, SOS1, binds to SOS1 with Kd of 7 uM but no H-Ras, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
NSC 658497 is a small molecule inhibitor of Ras GEF, SOS1, binds to SOS1 with Kd of 7 uM but no H-Ras, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity.
NSC 658497 showes dose-dependent efficacy in inhibiting Ras, downstream signaling activities, and associated cell proliferation.
| M.Wt | 438.428 | |
| Formula | C20H10N2O6S2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Evelyn CR, et al. Chem Biol. 2014 Dec 18;21(12):1618-28.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
