Chemical Structure : NSP-513
CAS No.:
179185-30-9
NSP-513
(NSP513)
Catalog No.: PC-25902Not For Human Use, Lab Use Only.
NSP-513 is a potent and selective phosphodiesterase 3 (PDE 3) inhibitor, shows antiplatelet, antithrombotic, and hemodynamic effects.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NSP-513 is a potent and selective phosphodiesterase 3 (PDE 3) inhibitor, shows antiplatelet, antithrombotic, and hemodynamic effects.
NSP-513 potently inhibits collagen-induced canine platelet aggregation with IC50 of 93 nM.
NSP-513 inhibits adenosine diphosphate (ADP)-induced canine platelet aggregation with IC50 of 0.15 uM.
NSP-513 decreases ADP-induced platelet aggregation, the presence of prostaglandin E1 (PGE1; 3 and 10 nM), with IC50 of 0.15 uM.
Orally administered NSP-513 (0.03-1 mg/kg) inhibited collagen-induced canine platelet aggregation in ex vivo antiplatelet aggregation studies.
Intraduodenally administered NSP-513 (0.01-0.03 mg/ kg) dose-dependently prevented thrombus formation without any changes in blood pressure, heart rate, or bleeding time.
Physicochemical Properties
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M.Wt
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339.44
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Formula
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C20H25N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-5-methyl-6-(4-((3-oxo-2-propylcyclohex-1-en-1-yl)amino)phenyl)-4,5-dihydropyridazin-3(2H)-one
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References
1. Hirose H, et al. J Cardiovasc Pharmacol. 2000 Apr;35(4):586-94.
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