Chemical Structure : NT-0249 free base
CAS No.:
2763617-38-3
NT-0249 free base
(NT0249)
Catalog No. : PC-25503Not For Human Use, Lab Use Only.
NT-0249 free base is a potent, specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-2550301
Biological Activity
NT-0249 free base is a potent, specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM.
Physicochemical Properties
M.Wt
459.57
Formula
C22H29N5O4S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Urea, N-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-N′-[[(1-methyl-1H-pyrazol-4-yl)[[(2S)-tetrahydro-2-furanyl]methyl]amino]sulfonyl]-
References
1. Thornton P, et al. J Pharmacol Exp Ther. 2024 Feb 15;388(3):813-826.
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