Chemical Structure : NT-0527
CAS No.:
2771019-10-2
NT-0527
(NT0527)
Catalog No.: PC-25502Not For Human Use, Lab Use Only.
NT-0527 is a highly potent, selective and brain penetrant and orally bioavailable NLRP3 inflammasome inhibitor, inhibits NLRP3 inflammasome-mediated IL-1β production triggered by multiple second stimuli (ATP, IC50=87 nM; CPPD, IC50=40 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NT-0527 is a highly potent, selective and brain penetrant and orally bioavailable NLRP3 inflammasome inhibitor, inhibits NLRP3 inflammasome-mediated IL-1β production triggered by multiple second stimuli (ATP, IC50=87 nM; CPPD, IC50=40 nM).
NT-0527 reduces IL-1β production from huWB with IC50 of 0.79 uM.
NT-0527 is a potent inhibitor of IL-1β release in a human whole blood assay and does not prevent the release of IL-6 or TNFα.
NT-0527 is selective for NLRP3 over other inflammasomes.
NT-0527 (1, 3, 10, 30 and 100 mg/kg, oral) is efficacious in LPS/ATP induced peritonitis in mice, inhibits the production of peritoneal IL-1β.
Physicochemical Properties
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M.Wt
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360.77
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Formula
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C17H14ClFN4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(6'-chloro-1'-oxo-1'H-spiro[cyclopropane-1,4'-isoquinolin]-2'(3'H)-yl)-N-(5-fluoropyrimidin-2-yl)acetamide
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References
1. Harrison D, et al. RSC Med Chem. 2025 Sep 4. doi: 10.1039/d5md00639b.
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