NV-128 (LY-303511) is a novel isoflavone derivative that inhibits mTOR and promotes caspase-independent cell death.
NV-128 induce significant cell death in both paclitaxel-resistant and carboplatin-resistant EOC cells with GI50 of 1-5 ug/mL.
NV-128 significantly depresses mitochondrial function by decrease in ATP, Cox-I, and Cox-IV levels, and by increase in mitochondrial superoxide and hydrogen peroxide.
Physicochemical Properties
M.Wt
306.365
Formula
C19H18N2O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one
References
1. Alvero AB, et al. Cancer. 2009 Jul 15;115(14):3204-16.
2. Alvero AB, et al. Mol Cancer Ther. 2011 Aug;10(8):1385-93.
