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Chemical Structure : NV-128
CAS No.: 154447-38-8
Catalog No.: PC-60555Not For Human Use, Lab Use Only.
NV-128 (LY-303511) is a novel isoflavone derivative that inhibits mTOR and promotes caspase-independent cell death.
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|---|---|---|---|
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| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
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NV-128 (LY-303511) is a novel isoflavone derivative that inhibits mTOR and promotes caspase-independent cell death.
NV-128 induce significant cell death in both paclitaxel-resistant and carboplatin-resistant EOC cells with GI50 of 1-5 ug/mL.
NV-128 significantly depresses mitochondrial function by decrease in ATP, Cox-I, and Cox-IV levels, and by increase in mitochondrial superoxide and hydrogen peroxide.
| M.Wt | 306.365 | |
| Formula | C19H18N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one |
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1. Alvero AB, et al. Cancer. 2009 Jul 15;115(14):3204-16.
2. Alvero AB, et al. Mol Cancer Ther. 2011 Aug;10(8):1385-93.
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