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Chemical Structure : NV-5297
Catalog No.: PC-49337Not For Human Use, Lab Use Only.
NV-5297 (NV5297) is a novel small molecule mTORC1 pathway activator, modulates the Sestrin2-Gator2 interaction and activates the mTORC1 pathway in vitro and in vivo.
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NV-5297 (NV5297) is a novel small molecule mTORC1 pathway activator, modulates the Sestrin2-Gator2 interaction and activates the mTORC1 pathway in vitro and in vivo.
NV-5297 is a leucine analog activating the mTORC1 pathway in the brain and peripheral tissues.
NV-5297 disrupted the Sestrin2/GATOR2 interaction in a dose-dependent manner in HEK293T cells stably expressing flag-WDR24, a component of GATOR2, NV-5297 treatment in leucine-starved cells also increased p70S6K1 in a dose-dependent manner.
NV-5297 activated mTORC1, increased striatal volume, improved motor learning and heart contractility in the N171-82Q huntington's disease (HD) mouse model, ameliorated motor behavior and striatal deficits in HD mice.
| M.Wt | 199.173 | |
| Formula | C7H12F3NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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