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Chemical Structure : NVP-AEW541
CAS No.: 475489-16-8
Catalog No.: PC-45879Not For Human Use, Lab Use Only.
NVP-AEW541 (AEW-541, AEW541) is a potent, and selective inhibitor of IGF-1R with IC50 of 86 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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NVP-AEW541 (AEW-541, AEW541) is a potent, and selective inhibitor of IGF-1R with IC50 of 86 nM.
NVP-AEW541 shows weak activity for closely related InsR (IC50=2.3 uM).
NVP-AEW541 inhibits IGF-IR autophosphorylation and abrogates IGF-I-mediated survival and colony formation in soft agar.
NVP-AEW541 inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas in vivo; orally bioavailable.
| M.Wt | 439.5521 | |
| Formula | C27H29N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 51 mg/mL |
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| Chemical Name/SMILES |
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]- |
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1. García-Echeverría C, et al. Cancer Cell. 2004 Mar;5(3):231-9.
2. Scotlandi K, et al. Cancer Res. 2005 May 1;65(9):3868-76.
3. Tanno B, et al. Clin Cancer Res. 2006 Nov 15;12(22):6772-80.
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