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Chemical Structure : NVP-AUY922
CAS No.: 747412-49-3
Catalog No.: PC-42461Not For Human Use, Lab Use Only.
NVP-AUY922 (Luminespib, AUY922) is a potent and selective HSP90 inhibitor with IC50 of 21 and 7.8 nM for HSP90β and HSP90α, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $58 | In stock | |
| 25 mg | $98 | In stock | |
| 50 mg | $148 | In stock | |
| 100 mg | $238 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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NVP-AUY922 (Luminespib, AUY922) is a potent and selective HSP90 inhibitor with IC50 of 21 and 7.8 nM for HSP90β and HSP90α, respectively.
NVP-AUY922 weakly inhibits HSP90 family members GRP94 and TRAP-1 (Ki=108 and 53 nM), shows no inhibition of HSP72 ATPase and little or no activity against a range of 13 kinases.
NVP-AUY922 inhibits proliferation of human tumor cells (GI50=2-40 nM), induces G(1)-G(2) arrest and apoptosis.
NVP-AUY922 exhibits in vivo activity against xenograft tumor growth, angiogenesis and metastasis.
| M.Wt | 465.5414 | |
| Formula | C26H31N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 62 mg/mL |
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| Chemical Name/SMILES |
3-Isoxazolecarboxamide, 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]- |
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1. Brough PA, et al. J Med Chem. 2008 Jan 24;51(2):196-218.
2. Eccles SA, et al. Cancer Res. 2008 Apr 15;68(8):2850-60.
3. Jensen MR, et al. Breast Cancer Res. 2008;10(2):R33.
4. Stühmer T, et al. Leukemia. 2008 Aug;22(8):1604-12.
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